7-Amino-3-cephem-4-carboxylic acid
ʻIke kumu:
inoa Pelekane:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- NACA、7-ANCA;7-ANCAChemicalbook haumia;CeftizoximeImpurity9;CeftizoximeImpurity16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
Helu CAS: 36923-17-8
Huina mole: C7H8N2O3S
Kaumaha molekula: 200.21
Helu EINECS: 609-312-7
Kumu hoʻolālā:
Nā waeʻano pili: Nā mea waena; Nā mea waena lāʻau lapaʻau; ʻO nā mea lāʻau lapaʻau.
Ka helu hehee: 215-218°C
Puni paila: 536.9±50.0 °C(Wānana ʻia)
Māmā: 1.69± 0.1g /cm3(Wānana ʻia)
Hōʻike hōʻano hou: 1.735 (manaʻo)
Kaila uila: 278.508°C
Hiki ke hoʻoheheʻe ʻia: Hiki ke hoʻoheheʻe ʻia i loko o ka wai ʻawaʻawa (ʻuʻuku, wela), DMSO (ʻuʻuku). Pono: Keʻokeʻo a keʻokeʻo crystalline pauka.
Pumi mahu: 0mmHg ma 25°C
| kikoʻī | hui | maʻamau |
| Ka nana aku | Keʻokeʻo a keʻokeʻo crystalline pauda | |
| Mea nui | % | ≥98.5% |
| Mākū | % | ≤1 |
| Mono hybrid | % | ≤0.5 |
| Huipuu nui | % | ≤1 |
ʻO Cephalosporin, hoʻohana ʻia ma ke ʻano he waena o cefbutan a me cefazoxime.
Hoʻohui ʻia ka waikawa sulfuric concentrated (104.3mL, 1.92mol) i loko o ʻekolu mau hue, a laila hoʻohui ʻia ka waikawa isophthalic (40g, 0.24mol), hoʻoulu ʻia a wela i 60 ℃, paʻa no 0.5h, a me 60% nitric acid (37.8g, 0.36). mol) i hoʻohui ʻia no ka hoʻomalu ʻana i ka degere holo wikiwiki. Hoʻohui i loko o 2 mau hola. Ma hope o ka hoʻohui, mālama ʻia ka wela ma 60 ℃ no 2 mau hola. Hoʻolili i lalo o 50 ° C, a laila hoʻohui i 100mL o ka wai. Hoʻomaʻalili ʻia ka mea i ka lumi wela, ninini ʻia i loko o ka kānana, hoʻomoʻi ʻia e wehe i ka waiʻona, holoi ʻia ka keke kānana me ka wai, hoʻokahe ʻia e recrystallize, a ʻo ka huahana keʻokeʻo he 34.6 grams, ʻo ka hua he 68.4%.
20Kg a i ʻole 25Kg/ bākeke, pahu pahu pahu, i hoʻopaʻa ʻia me kahi papa keʻokeʻo a me kahi ʻeke polyethylene ʻeleʻele. 2 ℃ -8 ℃ maloʻo, wahi anuanu, kahi mamao mai ka mālama māmā, kūpono no 2 mau makahiki.
