2-chloro-5-chloromethyl pyridine

Nui nā ʻano hana synthesis o 2-chloro-5-chloromethyl pyridine.I kēia manawa, hoʻohana ʻia ka 2-chloro-5-methylpyridine ma ke ʻano he mea maka i ka ʻoihana, ʻo ia hoʻi, 2-chloro-5-methylpyridine ka chlorinated e 2-chloro-5-methylpyridine i mua o kahi catalyst e loaʻa ai ka 2-chloro. -5-chloromethyl pyridine.Hoʻohui ʻia ka 2-chloro-5-methylpyridine a me ka solvent i ka ipu chlorination, ua hoʻohui ʻia ka catalyst, a ua hoʻokomo ʻia ke kinoea chlorine i loko o ka hopena ma lalo o ke kūlana reflux.Ma hope o ka hopena, ua hoʻoheheʻe ʻia ke kaomi o ka lewa mua, a laila hoʻoneʻe ʻia ka hakina mua ma ka ʻōpala i loko o ka ipu hoʻoheheʻe, a loaʻa ka 2-chloro-5-methylpyridine mai lalo o ka ipu hao.Ma waho aʻe o ka , aia nā ʻano ala like ʻole e hoʻohana ana i ka niacin ma ke ʻano he maka, 3-methylpyridine ma ke ʻano he maka, 2-chloro-5-trichloromethyl pyridine ma ke ʻano he mea maka.ʻO kahi hiʻohiʻona maʻamau o kēia mau ʻano ka hoʻokumu ʻana o kahi apo pyridine i ukali ʻia e ka hoʻopau ʻana o ka chloromethylation.ʻO kahi ala ʻē aʻe i hoʻomohala ʻia e ka United States Rayleigh Company (ReillyIndustriesInc.) e lawe i ka cyclopentadiene a me propanal e like me ka hoʻomaka ʻana i nā mea maka e cyclosynthesize pololei i ka 2-chloro-5-chloromethyl pyridine, a ʻo ka maʻemaʻe o ka huahana e like me 95%, me ka ʻole o ka isomer 2 -chloro-3-chloromethyl pyridine.